Chinese Journal of Neuromedicine 2025;24(2):201-206

doi:10.3760/cma.j.cn115354-20240924-00591

Recent advance in mesenchymal stem cell exosome in Alzheimer's disease

Shijun HU 1 ; Yumeng LI ; Tao LIU

Affiliations

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Keywords

Alzheimer's disease; Mesenchymal stem cell-derived exosome; Mesenchymal stem cell; Nano-drug; Engineered exosome; Therapeutic mechanism

Country

China

Language

Chinese

Abstract

Alzheimer's disease (AD) is the leading neurodegenerative disorder in the nervous system, and there is still a lack of effective therapeutic drugs. Protecting neurons and synapses is crucial in reversing AD progression. Mesenchymal stem cell-derived exosome (MSC-Exo) is rich in various stem cell components such as proteins, RNAs, and DNAs; due to its strong ability in promoting nerve repair and inhibiting neuroinflammation, MSC-Exo is expected to become a potential choice for AD treatment. This article elaborates on the biological characteristics of MSC-Exo and its application and progress in AD treatment, aiming to provide reference for translational medicine research and clinical application of MSC-Exo in AD.