Chinese Journal of Psychiatry 2021;54(4):300-304

doi:10.3760/cma.j.cn113661-20200922-00412

Recent advances in mismatch negativity of schizophrenia

Shuqi XU 1 ; Jinling WAN 1 ; Jinsheng MA 1 ; Xueyi WANG 1 ; Ran WANG 1

Affiliations

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Keywords

Schizophrenia; Evoked potentials; Mismatch negativity

Country

China

Language

Chinese

Abstract

Mismatch negativity (MMN) is an endogenous component of event-related potential that occurs with deviation stimulus. It has been widely used as a biomarker in schizophrenia-related researh. Studies have shown that MMN is correlated with early diagnosis of mental illness, cognitive impairment, and social-behavioral dysfunction in psychiatric patients. Further studies on relevant mechanisms would be conducive to understand the electrophysiological, cognitive, and behavioral changes of mental diseases and provide a new treatment strategy. This review introduces the latest progress in basic research and clinical application of MMN in schizophrenia, discusses the future research direction of MMN, and provides evidence for further research.