Journal of Capital Medical University 2025;46(4):733-741

doi:10.3969/j.issn.1006-7795.2025.04.023

Research progress on the long-term effects of subthalamic nucleus deep brain stimulation on non-motor symptoms in Parkinson's disease

Chenguan JIANG 1 ; Yan LIU 1 ; Zhou YANG 1 ; Bingxin LI 1 ; Jianguo ZHANG 1 ; Lin SHI 1

Affiliations

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Keywords

Parkinson's disease; subthalamic nucleus; deep brain stimulation; cognitive function; affective disorders; autonomic dys-function

Country

China

Language

Chinese

Abstract

Deep brain stimulation(DBS)has witnessed rapid advancement as a neurosurgical intervention over the past four decades,addressing movement disorders and a spectrum of neuropsychiatric conditions.Notably,subthalamic nucleus deep brain stimulation(STN-DBS)is widely implemented in the management of Parkinson's disease(PD)patients experiencing refractory motor fluctuations and complications,and has shown promise in ameliorating non-motor symptoms(NMS).However,the long-term efficacy of STN-DBS on NMS remains a subject of scholarly discourse.This review endeavors to synthesize current knowledge regarding the long-term impacts,underlying mechanisms,and future research directions of STN-DBS in the context of NMS in Parkinson's disease.