Tumor 2025;45(2):137-141

doi:10.3781/j.issn.1000-7431.2025.2306-0314

Microsatellite instability-high metastatic gastric cancer treated with immunotherapy combined with chemotherapy:A case report and literature review

Zhihong XU 1 ; Qian ZHANG 1 ; Hui JIN 1

Affiliations

+expand

Keywords

Gastric cancer; Microsatellite instability-high; Immunotherapy; Chemotherapy; Tumor microenvironment

Country

China

Language

Chinese

Abstract

Gastric cancer is one of the malignant tumors with strong invasion and heterogeneity.Individualized treatment of gastric cancer based on precise classification guidance is currently a research hotspot.Microsatellite instability-high(MSI-H)gastric cancer has specific clinical features,tumor microenvironment,and pathological characteristics,which have been used as tumor markers to evaluate the prognosis of gastric cancer patients.In recent years,immunotherapy has brought new hope for the treatment of gastric cancer patients,among whom MSI-H patients are considered the advantageous population for immunotherapy.This paper reports a case of MSI-H metastatic gastric cancer receiving immunotherapy combined with chemotherapy,and provides reference for clinical practice based on literature review.