Tumor 2024;44(3):290-295

doi:10.3781/j.issn.1000-7431.2024.2402-0095

Advances in the research of exosomes in castration-resistant prostate cancer

Qi CHEN 1 ; Liang DONG 1 ; Wei XUE 1

Affiliations

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Keywords

Prostate cancer; Castration-resistant prostate cancer; Exosomes

Country

China

Language

Chinese

Abstract

Exosomes are extracellular vesicles released by living cells,characterized by typical lipid bilayer structure,with diameters ranging between 30 nm and 200 nm.By transferring biomacromolecules and modulating related signaling pathways,exosomes play a role in the development and progression of tumors,including tumor cell proliferation,angiogenesis,tumor microenvironment remodeling,metastatic niche establishment,and drug resistance.Exosomes associated with prostate cancer significantly contribute to the promotion of the transition of prostate cancer to a castration-resistant phenotype.This article primarily summarizes the latest advances in the research of exosomes in castration-resistant prostate cancer.