Objective:To evaluate the efficacy and safety of endoscopic balloon dilation (EBD) in the treatment of Crohn′s disease (CD) with intestinal stenosis.Methods:Clinical data of 8 CD patients with intestinal stenosis undergoing EBD in the First People′s Hospital of Changzhou from January 2018 to November 2019 were retrospectively summarized. Efficacy of short- and long-term, associated complications and outcomes of EBD were analyzed.Results:There were 18 stenoses in 8 patients, including 16 primary stenoses and 2 anastomotic stenoses. Two stenoses located in ileocecal valve, 7 in ileum, 6 in jejunum, 2 in transverse colon, 1 in duodenal bulb. The median number and average length of stenoses were 2 per patient and (3.15±0.37) mm respectively. A total of 12 times of EBD were performed in 8 patients, including 3 times in each of 2 patients. The dilation was performed successfully in 16 of 18 stenoses in the first EBD procedure. The technical successful rate of the first EBD was 88.9% (16/18) . One dilation of anastomotic stenosis in ileum was failed because of intestinal shift and angulation deformity, and the other dilation of ileum stenosis was failed because of its length ≥5 cm. The mean intestinal diameter of stenosis was (8.89±1.36) mm before dilation and (15.10±1.62) mm after dilation, whose difference was significant ( t = 9.40, P<0.01) . The abdominal obstruction was relieved in 7 patients after EBD and the CT reexamination showed that the intestinal obstruction was relieved or disappeared. The other 1 patient did not obtain the relief of abdominal symptom and received surgery in other hospital. No operation-related complications occurred in 8 patients. All the patients were followed up for 6 to 24 months, three times of EBD were performed in each of 2 patients within 1 year after the first EBD and the mean interval of EBD was 70 (53, 94) d. Conclusion:EBD is safe and effective in the treatment of CD with intestinal stenosis, and serious complication is rare.