[Purpose]To analyze the survival of colorectal cancer patients in Jiashan County of Zhejiang Province from 1991 to 2020.[Methods]The data of newly reported cases of colorectal cancer were collected in Jiashan County from January 1,1991 to December 31,2020,and pa-tients were followed-up till December 2023.The observed survival rate(OSR)and relative survival rate(RSR)were calculated using the life table and Ederer Ⅱ method with 5-year intervals.Rela-tive survival was adjusted using the International Cancer Survival Standards.The Joinpoint re-gression model was used to calculate the average annual percentage change(AAPC)to analyze the change trend of survival rate.[Results]The 5-year RSR of colorectal cancer increased from 21.7％during 1991 to 1995 to 73.4％during 2016 to 2020,showing an increasing trend(AAPC=4.6％,P＜0.05),for men it increased from 17.7％to 72.7％and for women it increased from 30.0％to 74.3％,with AAPCs of 3.9％and 4.3％,respectively(P＜0.05).The 5-year RSR of colorectal can-cer in all age groups showed an increasing trend(P＜0.05 for all age groups,except for 75+),and the highest increase was found in the age group of 65～74 years old(AAPC=4.9％).[Conclusion]From 1991 to 2020,the 5-year survival rate of colorectal cancer in Jiashan County showed a steady increase,for women and those aged 65～74 years old the increase was more significant.The cancer screening of high-risk groups should be focused on to improve colorectal cancer survival rate.