A 68-year-old male patient with lung cancer received the treatment of combination of pemetrexed disodium and bevacizumab. About 20 minutes after finishing the IV infusion of pemetrexed disodium injection,the patient suddenly developed suppression in the chest,dyspnea,hyperhidrosis,pale, and cyanosis of lips. His heart rate was 98 beats/ min,breathing rate was 24 / min,and blood pressure was 70 / 40 mmHg. He was diagnosed as anaphylactic shock due to pemetrexed disodium. The patient was given nasal catheter oxygen inhalation and ECG monitoring,intravenous injection of adrenalin (1 mg)and dexamethasone (20 mg),immediately. Thirty minutes later,his symptoms were relieved. About 2 hours after the end of IV infusion of pemetrexed disodium,skin rashes occurred on the patient′s chest. He received intramuscular injection of phenergan 12. 5 mg,immediately. Twenty-six minutes later,the rashes disappeared. About 20 minutes after the subsiding of the rashes,he received IV infusion of bevacizumab. The patient did not develop any symptoms.