Adverse Drug Reactions Journal 2000;2(3):159-164

doi:10.3760/j.issn.1008-5734.2000.03.005

Examination of antibacterials in clinical use

Yueling LI 1 ; Zuojun HUANG 1 ; Yuanshan WU 1 ; Qikun ZHENG 1

Affiliations

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Keywords

antibacterials; clinical use; analysis

Country

China

Language

Chinese

Abstract

Objective:To check if antibacterials were rational in clinical use.Methods:143 inpatients between June and December 1998 were enrolled for retrospective analysis of drug administration.Results:132 cases took an tibacterial drugs accounting for 92.3％,among them 69 cases (52.3％) for treatment and 63 cases (47.7％) for preventive purposes.From the said patients only 16 samples were collected and sent for bacterial culture,its positive rate being 31.5 ％.Antibacterials taken covered 43 kinds of 10 categories,altogether 1573 drug-days.The rate of the unreasonable application was 39.4 ％ (52/132 cases) or 42.5 ％ (668/1573 drug-days).Medication for wrong indications or for a longer period than neccessity could be the main problem.Conclusion:In order to upgrade the diagnostic and therapeutic level,medical professionals should have knowledge of and be familiar with antibacterials and use them in a reasonable way in combination with bacterial culture and drug sensitivity test,if possible.