Acta Parasitologica et Medica Entomologica Sinica 2002;9(4):204-209
doi:10.3969/j.issn.1005-0507.2002.04.003
DETECTIONS OF ADHESION MOLECULE AND CYTOKINES IN NEUROCYSTICERCOSIS PATIENTS
Keywords
Neurocysticercosis; Adhesion molecule; Cytokines; Detection
Country
China
Language
Chinese
Abstract
In 30 neurocysticercosis patients,their levels of soluble intercellular adhesion molecule-1(sICAM-1),interleukin-8(IL-8),and soluble interleukin-2 receptor (sIL-2R) in the serum,and the levels of IL-2,interferon gamma (IFN-γ) and tumor necrosis factor alpha (TNF-α) in the supernatant of their peripheral blood mononuclear cell (PBMC) culture were assayed.The expression of CD11a,CD11b and CD18 molecules on the PBMC of the patients and the controls were tested as well.The levels of slCAM-1,IL-2,and IFN-γ of the patients were lower than those of the control group,but the levels of IL-8,sIL-2R and TNF-α were higher than that in the control group.The percentage of the CD11b positive cell in the patients was significantly higher than that of controls.But the amount of CD 11a expressed on patients PBMC surface was lower than ther of controls.As to CD18,there was no significant difference between the two groups.The relations between these factors and immune functions were discussed.
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