China Cancer 2025;34(2):159-164

doi:10.11735/j.issn.1004-0242.2025.02.A011

Roles of Prostaglandin E Receptor in Tumor Microenvi-ronment and Its Potential Application in Cancer Therapy

Xiaoyu WU 1 ; Jiong DENG ; Tong WANG

Affiliations

+expand

Keywords

prostaglandin E receptor; prostaglandin E2; tumor microenvironment; cancer therapy

Country

China

Language

Chinese

Abstract

Prostaglandin E2(PGE2)regulates a variety of cells in tumor microenvironment(TME)and plays an important role in tumor growth,metastasis and immunity.PGE2 activates different downstream signaling pathways through its key receptor prostaglandin E receptor(EP4),regulating inflammation,immune cell function and angiogenesis to promote or inhibit tumor development.EP4 shows potential application values in adjuvant chemotherapy and immunotherapy as an emerging anti-tumor target.However,future studies on the roles of EP4 in tumor microenvironment,develo-pment of safer and more effective EP4 drugs,and its application in personalized immunotherapy are needed.