Objective To explore the effect of wound-bed preparation sequential plan on wound healing following tibiofibula open fracture .Methods Forty-six patients with postsurgical unsealed wound following tibiofibula open fracture , who were admitted into the Navy General Hospital from May 2011 to May 2014 were selected for our study .With the knowledge and consent of the patients , the patients were randomly divided into 2 groups:the wound-bed preparation sequential plan group ( or simply the sequential plan group ) (n=23) and the control group (n=23).Evaluation indicators included:improvement of wound surface, total time of wound surface healing and standard wound surface healing time .Results No.of days when fresh granulation appeared for the sequential plan group were (4.30 ±1.49) d, which were shorter than those of the routine treatment group (6.00 ±2.31) d, with statistical significance (P=0.001).Total time of wound surface healing and standard wound surface healing time for the sequential plan group were respec -tively (36.00 ±12.74) d and (2.01 ±0.69) d/cm3 .However, for the routine treatment group , total time of wound surface healing and standard wound surface healing time were respectively (51.70 ±16.45) d and (2.60 ±1.03) d/cm3 , and statistical significance could be noted, when comparisons were made between the 2 groups(P=0.001, 0.027).Conclusion When used in the treatment of postsurgical unsealed wound following tibiofibula open fracture , the standard wound-bed preparation sequential plan was beneficial to the improvement of wound bed , enhancement of granulation and acceleration of wound healing .