Objective To study the safety and efficacy of oral lactulose coupled with bifico as pre-surgical bowel preparation in patients with primary liver cancer .Methods With the knowledge and consent of the patients , a total of 80 patients were randomly divided into 2 groups, the experimental group and the control group , each consisting of 40 patients.The experimental group received o-ral lactulose plus bifico and the control group was given oral polyethylene glycol electrolytes as pre -surgical bowel preparation before sur-gery.Then, patients′tolerance, acceptance, adverse reactions, bowel cleansing and post-surgical bowel movement recovery were ob-served and compared between the 2 groups.Results No statistical significance in bowel cleansing could be observed , following imple-mentation of the drugs for the two groups (P>0.05).The texture and acceptance of the drugs for the experimental group were obviously superior to those of the control group, with statistical significance(P<0.05).With the exception of allergic reaction, no statistical difference could be noted in adverse reactions to pre-surgical bowel preparation for both groups (P>0.05).The incidence of other ad-verse reactions for the experimental group was lower than that of the control group , with statistical significance(P<0.05).Following pre-surgical bowel preparation , frequency of defecation and recovery of liver function for the experimental group were superior than those of the control group, also with statistical significance, when comparisons were made between the 2 groups (P<0.05).Conclusion Lactulose coupled with bifico as pre-surgical bowel preparation was safe and feasible , which could not only improve the sense of comfort for the patients, but increased their compliance , and decreased medical cost as well .