Objective To explore the effects of comprehensive nursing intervention measures on the prevention of pre -surgical anxiety in patients having elective neurosurgery .Methods In accordance with different nursing methods , 286 patients, who received neurosurgical treatment in the Neurosurgery Department of our hospital from Jan , 2011 to May, 2012, were divided into 2 groups:the experimental group (150 cases) and the control group (136 cases).The patients in the control group received routine nursing care , be-fore elective neurosurgical surgery .In addition to routine nursing care , the patients in the experimental group received intensified psy-chological care plus comprehensive nursing interventions , such as musical therapy , massage, graphic beckoned card and better commu-nications between patients and nurses .Then, anxiety values were compared between the 2 groups.Results Pre-surgical anxiety value of the patients in the experimental group was (46.0 ±5.1), which was lower than (61.0 ±7.0) of the control group.And statistical significance could be seen, when comparisons were made between them (P<0.01).Conclusion Comprehensive nursing intervention could significantly decrease pre-surgical anxiety of elective surgical patients and proved to be helpful to the performance of surgery and recovery of patients .