JOURNAL OF RARE DISEASES 2025;4(4):419-425

doi:10.12376/j.issn.2097-0501.2025.04.004

Clinical Diagnosis and Treatment Strategies for Ovarian Immature Teratoma

Jie YANG 1 ; Jiaxin YANG 1 ; Na SU 2 ; Xiaohua SHI 3 ; Dongyan CAO 1 ; Peng PENG 1 ; Yang XIANG 1 ; Jinghe LANG 1

Affiliations

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Keywords

ovarian immature teratoma; malignant germ cell tumor; diagnosis; treatment

Country

China

Language

Chinese

Abstract

Ovarian immature teratoma is a relatively rare malignant ovarian tumor that predominantly occurs in children, adolescents, and young adults. In clinical diagnosis and treatment, tumor marker detection and imaging examinations serve as crucial bases for differentiating mature and immature terotomas. A comprehensive preoperative evaluation followed by the selection of an appropriate surgical approach and extent is key to improving prognosis. Some studies have indicated that for stage Ⅰ ovarian immature teratoma, avoiding adjuvant chemotherapy under close follow-up does not increase the risk of recurrence or affect long-term survival of patients; however, for advanced-stage ovarian immature teratoma, standardized postoperative chemotherapy is still recommended. Some patients may experience benign-malignant transformation of malignant germ cell components after surgery, such as growing teratoma syndrome or squamous cell carcinoma transformation. Due to the rarity of ovarian immature teratoma, current understanding of its pathogenesis and clinical management remains limited. This paper provides a review focusing on key clinical issues related to ovarian immature teratoma and proposes corresponding diagnostic and therapeutic recommendations, aiming to offer references for promoting multidisciplinary collaboration and individualized treatment.