Acta Parasitologica et Medica Entomologica Sinica 2001;8(1):1-6

doi:10.3969/j.issn.1005-0507.2001.01.001

PRELIMINARY STUDIES ON MOUSE PLASMODIUM YOELII MODEL FOR THE EVALUATION OF A MULTI-EPITOPE VACCINE CANDIDATE OF PLASMODIUM FALCIPARUM

Wenqi DONG 1 ; Huixang BI ; Ming LI ; Lizhi QU

Affiliations

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Country

China

Language

Chinese

Abstract

To find a suitable animal model for the vaccine assessment of Plasmodium falciparum,Plasmodium yoelii and Plasmodium berghei of mouse were used to evaluate the protection for a multi-epitope vaccine candidate of Plasmodium falciparum. Results showed that mice of the group firstly immunized with the protein expressed in E.coli,then boosted with the recombinant vaccinia virus from the same epitopes survived longer than that of groups immunized with the wild vaccinia virus or the blank control (P<0.01).This indicates that Plasmodium yoelii of mouse could be used as a protective model for the evaluation of multi-epitope vaccine candidate of Plasmodium falciparum.