Cancer Research on Prevention and Treatment 2025;52(11):945-950

doi:10.3971/j.issn.1000-8578.2025.25.0278

Clinical Effects of Intercostal Nerve Block Analgesia and Patient Controlled Intravenous Analgesia in Enhanced Recovery After Minimally Invasive Surgery for Lung Cancer: A Prospective Randomized Controlled Trial

Ziyi ZHAO 1 ; Yun YE 2 ; Xi CHEN 3 ; Long TIAN 1 ; Xi ZHENG 1 ; Guowei CHE 1

Affiliations

+expand

Keywords

Intercostal nerve block analgesia; Patient controlled intravenous analgesia; Enhanced recovery after surgery; Lung cancer

Country

China

Language

Chinese

Abstract

Objective To compare the analgesic effects and adverse reactions between intercostal nerve block (ICNB) and patient controlled intravenous analgesia (PCIA). Methods From August 2022 to January 2023, 180 patients with lung cancer who underwent thoracoscopic surgery were randomly divided into two groups: ICNB group (n=90) and PCIA group (n=90). The postoperative pain degree (VAS), location, nature; adverse events, such as nausea, vomiting, and dizziness; and other clinical symptoms were analyzed. Results The most common site of postoperative pain in both groups was surgical incision, and the nature of pain was distending pain. At 12 and 24 h after the operation, the pain degree in the ICNB group (1.10±0.91, 3.12±1.29) was markedly lower than that in PCIA group (1.44±0.86, 4.32±1.30, P=0.010, P<0.001). The incidence of nausea, vomiting, and dizziness in the ICNB group (5.56%, 23.33%) was noticeably lower than that in the PCIA group (35.56%, 51.11%, P<0.001, P<0.001). Total hospitalization expense in the ICNB group (41 043.16±10 885.63 yuan) was significantly lower than that in PCIA group (45 283.99±11 036.36 yuan, P=0.010). Conclusion The analgesic effect of intercostal nerve block is better than that of patient-controlled intravenous analgesia pump in patients with lung cancer after minimally invasive surgery, and the incidence of adverse reactions is low.