Objective To analyze the use of non-national immunization program(nNIP) vaccines in Liaoning Province from2018 to 2024, evaluate the current situation of nNIP vaccination in Liaoning Province, and to provide scientific basis for formulating public health policies and optimizing vaccination strategies.Methods The nNIP vaccination data from 2018 to2022 and 2023 to 2024 were extracted through “China Immunization Program Information Management System” and“Liaoning Province Immunization Program Comprehensive Information Platform-Vaccination Information System”, including nNIP vaccine replacement records. Pearson correlation coefficient matrix analysis was performed using SPSS 13.0 software,and descriptive analysis method was used to comprehensively analyze the data.Results From 2018 to 2024, a total of25 726 024 doses of nNIP vaccines were administered in Liaoning Province, with per capita dose of 866 doses per 10 000 people. The per capita doses of nNIP vaccine and the proportion in total doses of all vaccines were increasing year by year.The top three nNIP vaccine varieties used were rabies vaccine for human use(Rab), influenza vaccine(InfV) and varicella attenuated live vaccine(VarV). Among the NIP, poliomyelitis vaccine(PV) showed the highest substitution rate(30. 40%),followed by hepayitis A attenuated live vaccine(HepA-L)(29. 08%) and diphtheria,tetanus and acellular pertussis combined vaccine(DTaP)(16. 37%).Conclusion The importance of nNIP vaccines in public health has become increasingly prominent. As an important part of vaccination, the quality of surveillance needs to be further strengthened. The nNIP vaccines can make up for the lack of NIP vaccine coverage, and can also play an important role when some NIP vaccines are temporarily in short supply. On the basis of optimizing the supply and distribution of NIP vaccines, increasing the level of nNIP vaccination can effectively prevent and control the epidemic of vaccine-preventable infectious diseases.