Journal of Pharmaceutical Practice and Service 2025;43(12):583-590

doi:10.12206/j.issn.2097-2024.202312024

Research progress on immunomodulatory effects and role of bile acids and bile acid receptors in the occurrence and development of colorectal cancer

Zhijun LIU 1 ; Lili CUI 2 ; Fengjing XU 2 ; Xinhua SONG 2 ; Zhipeng WANG 2 ; Shouhong GAO 1

Affiliations

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Keywords

colorectal cancer; bile acids; bile acid receptor; immunoregulation

Country

China

Language

Chinese

Abstract

Colorectal cancer is one of the most common malignant tumors, which is a great threat to human life and health. The change of bile acid homeostasis can activate their corresponding receptors to regulate the immune functions, which is closely related to the occurrence of colorectal cancer. In addition, some bile acids can directly induce colorectal cancer and play an important role in the development of colorectal cancer. In this paper, the metabolic process of bile acids in vivo and the immunomodulatory role of bile acid receptors were reviewed, and the evidence of associations between bile acids and colorectal cancer were summarized, which showed the rebalancing the bile acid levels might play a role in the prevention or treatment of colorectal cancer.