Medical Journal of Peking Union Medical College Hospital 2025;16(6):1413-1418

doi:10.12290/xhyxzz.2025-0721

Research Progress on the Clinical Efficacy and Safety of Telitacicept in the Treatment of IgA Nephropathy

Jiangman SONG 1 ; Xuelin SUN 2 ; Zhe XU 3 ; Li ZHENG 4

Affiliations

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Keywords

IgA nephropathy; pathogenesis; Telitacicept; clinical efficacy; safety

Country

China

Language

Chinese

Abstract

Immunoglobulin A nephropathy (IgAN) is the most common primary glomerular disease worldwide, accounting for 20%-40% of primary glomerulonephritis cases. Approximately 40% of patients progress to end-stage renal disease within 20 years. Traditional treatments primarily involve renin-angiotensin system inhibitors and glucocorticoids, but some patients show limited response and face infection risks. In recent years, the dual-target biologic agent Telitacicept, which targets B cell-activating factor/B lymphocyte stimulator(BAFF/BLyS) and a proliferation-inducing ligand (APRIL), has demonstrated significant potentialin the treatment of IgAN. By simultaneously neutralizing BAFF/BLyS and APRIL, Telitacicept suppresses abnormal B-cell activation and the production of pathogenic IgA1, significantly reducing urinary protein levels and preserving renal function. This article systematically reviews its mechanism of action, clinical efficacy, and safety, aiming to provide insights for the clinical management of IgAN.