Medical Journal of Peking Union Medical College Hospital 2025;16(6):1371-1375

doi:10.12290/xhyxzz.2025-0782

Risk of Drug-induced Thrombosis in Patients with Inflammatory Bowel Disease and Preventive Strategies

Yawen LIU 1 ; Yuge WEI 2 ; Zuoyan WU 1 ; Xiaomao GAO 1 ; Hong YANG 2

Affiliations

+expand

Keywords

inflammatory bowel disease; therapeutic drugs; thrombosis

Country

China

Language

Chinese

Abstract

Inflammatory bowel disease (IBD), a chronic inflammatory condition of the gastrointestinal tract, is associated with a significantly increased risk of both venous and arterial thromboembolism. Common risk factors for thrombosis include disease activity, surgery, older age, central venous catheterization, etc. However, thrombotic events related to pharmacological treatment are often under-recognized, despite their potential for severe consequences. With the rapid expansion of therapeutic options for IBD in recent years, it has become increasingly important to acknowledge that different agents carry varying levels of thrombotic risk. This review summarizes current evidence on the thrombotic risks associated with IBD therapies and outlines preventive strategies, aiming to optimize the thrombosis risk management and reduce treatment-related thrombotic events in IBD patients.