Medical Journal of Peking Union Medical College Hospital 2025;16(5):1096-1101

doi:10.12290/xhyxzz.2024-0508

Clinical Decision-making for Anti-infective Therapy in Patients with Positive Blood Cultures

Yan SHI 1 ; Xiaojun MA 2

Affiliations

+expand

Keywords

bloodstream infection; antimicrobial therapy; antimicrobial drug resistance; prognosis

Country

China

Language

Chinese

Abstract

Bloodstream infections(BSIs) are associated with high morbidity and mortality. The widespread emergence of antimicrobial resistance has significantly increased the complexity of treating BSIs, making the development of precise antimicrobial treatment strategies based on positive blood culture results a critical clinical challenge. Additionally, it is imperative to systematically correct traditional misconceptions to optimize treatment outcomes and alleviate the pressure of antimicrobial selection. This article provides an in-depth exposition across the following dimensions, including bloodstream infection diagnosis, infection source identification, antimicrobial treatment regimen formulation, etc., to optimize the diagnostic and therapeutic process for patients with positive blood culture results.