Medical Journal of Peking Union Medical College Hospital 2025;16(5):1073-1081

doi:10.12290/xhyxzz.2025-0704

Global Status of Antimicrobial Resistance and Corresponding Therapeutic Strategies

Xuesong XU 1 ; Yao WANG 2

Affiliations

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Keywords

microbial resistance; bacterial resistance; fungal resistance; microbial stewardship; control strategies; clinical treatment

Country

China

Language

Chinese

Abstract

With the widespread use of antimicrobial agents, the issue of microbial drug resistance has become increasingly severe, emerging as a major global public health challenge. Worldwide, there are significant differences in the types of drug-resistant bacteria, their epidemiological trends, and their resistance mechanisms. This article aims to review the current global status of microbial drug resistance, with a focus on the epidemiological trends, resistance mechanisms, and corresponding clinical treatment strategies for common drug-resistant bacteria and fungi, in order to provide a theoretical basis for promoting the rational use of antimicrobial agents.