Even with the advances in chemotherapeutic procedures and agents, chemotherapy may cause certain side effects that impair patients’ quality of life. Cancer treatment can lead to various other side effects, such as xerostomia, mucositis, dental caries, opportunistic infections, hypogeusia, dysgeusia, hyposalivation, and medication-related osteonecrosis of the jaw. The oral cavity is a common site of discomfort and pain caused by chemotherapy. In this paper, I will discuss the dental considerations for patients undergoing chemotherapy and cover how to address dental problems and what to consider when consulting with dentists.