Medical Journal of Peking Union Medical College Hospital 2025;16(2):330-337

doi:10.12290/xhyxzz.2025-0028

Research Progress on the Mechanism of Lipocalin-2 in Neurological Diseases

Yongtai ZHOU 1 ; Zhenyu YANG 1 ; Yan LI 1 ; Jiajing WU 1 ; Bo ZHAO 2

Affiliations

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Keywords

lipocalin-2; cerebrovascular disease; cognitive impairment diseases; neurodegenerative disease; anxiety disorders; depression

Country

China

Language

Chinese

Abstract

Lipocalin-2 (LCN2), a member of the human lipocalin family, has been demonstrated to be closely associated with diabetes, cardiovascular diseases, and renal disorders. Recent studies have indicated that LCN2 plays a significant regulatory role in the pathogenesis and progression of various neurological diseases by mediating pathways such as inflammation, oxidative stress, and ferroptosis. This article reviews the research advancements on the mechanism of LCN2 in neurological disorders, including cerebrovascular diseases, cognitive impairment disorders, Parkinson's disease, depression, and anxiety disorders, aiming to enhance clinical understanding.