Objective To investigate predictive value of combined lung injury prediction score(LIPS)and acute physiology and chronic health evaluation Ⅱ(APACHE Ⅱ)scores in patients with severe traumatic brain injury(sTBI)complicated with acute lung injury(ALI).Methods Seventy-five sTBI patients admitted to Provincial Hospital of Anhui Medical University from January 2019 to December 2021 were retrospectively selected and divided into ALI group(n=24)and non-ALI group(n=51)according to whether they were complicated with ALI.Basic data,laboratory indicators,APACHE Ⅱ score,LIPS score and Glasgow coma scale(GCS)score were collected.Logistic regression was used to analyze the risk factors of patients with sTBI complicated with ALI,and predictive value of the evaluation index of the receiver operating characteristic(ROC)curve for sTBI complicated with ALI was drawn.Results APACHE Ⅱ score and LIPS score in ALI group were significantly higher than those in non-ALI group,GCS score and red cell volume distribution width were significantly lower than those in non-ALI group(P<0.05).Logistic regression analysis showed that APACHE Ⅱ score,LIPS score and GCS score were independent risk factors for sTBI complicated with ALI(P<0.05).ROC curve analysis showed that area under the curve(AUC)of LIPS score and APACHE Ⅱ score in the diagnosis of sTBI complicated with ALI were 0.869 and 0.754,respectively.The AUC was 0.916(95％CI:0.855-0.976),and the sensitivity and specificity were 83.4％and 84.3％,respectively.Conclusion LIPS score combined with APACHE Ⅱ score can effectively predict the risk of sTBI complicated with ALI.