OBJECTIVE：To observe the antitumor effects and toxic reaction of carboplatin and Xiaozhiling after intratumor administration in mice with solid S180 tumor.METHODS:30 and 60 mg/kg carboplatin to 10 ml/kg xiaozhiling were administered intratumorally and 30mg/kg carboplatin intravenously every three day for one week in mice with transplanted tumor.The weights of tumor and body,the index of spleen and thymusgland were measured.RESULTS:Compared with normal saline group,the growth of tumor in 30,60 mg/kg carboplatin-treated and 10 ml/kg xiaozhiling groups was all inhibited,with inhibitory rates of 27.4%,41.9% and 25.6%,respectively.The indexes of spleen were decreased by 38.6% and 49.8%,and thymusgland 4.9% and 14.2% in mice treated with 30 and 60 mg/kg carboplatin,while the indexes of spleen and thymusgland in mice treated with Xiaozhiling were increased by 13.2% and 33.5%,respectively.The average mouse weights had no significant difference in every group.CONCLUSION:Carboplatin and xiaozhiling showed significant antitumor effects when injected intratumorally.The indexes of immune organs was decreased by carboplatin,while increased by Xiaozhiling.