OBJECTIVE:To evaluate the therapeu tic effectiveness of repaglinide in lowering the FBG and PPBG in type 2 diabetes among 68 patients.METHODS:68 cases were divided at random into two groups:Repaglinide group(34 patients, 17female, 17male) and Placebo-controlled gr oup(34 patients,16female and 18male).0.5mg repaglinide was taken orally before e ach meal in therapeutic group for 4 weeks,while the cases in control were treate d by placebo.RESULTS:Repaglinide could effectively decrease the leve ls of FBG,PPBG and HbA1C with significant difference when compare with the place bo(P<0.01).At the meantime,it could also lower the Cholesterol and triglyceride levels when compared with the control group(P<0.01).CO NCLUSION:Repaglinide was effective in lowering the levels of FBG,PPBG and HbA1C in type 2 diabetes patients without obvious side effects.