Objective? To explore the effects of mindfulness-based stress reduction on post-traumatic growth and quality of life among postoperative breast cancer patients. Methods? From June 2017 to December 2017, we selected 112 postoperative breast cancer patients of breast department at a classⅢ grade A cancer hospital in He'nan Province as subjects by convenience sampling. All of the patients were divided into control group and observation group with the method of random number table, 56 cases in each group. Control group adopted routine nursing intervention. On the basis of routine nursing, observation group carried out mindfulness-based stress reduction for 8 weeks. The intervention effects were evaluated with the Posttraumatic Growth Inventory (PTGI) and the Functional Assessment of Cancer Therapy-Breast (FACT-B). Results? Before intervention, there were no statistical differences in the total score and dimension scores of PTGI of patients between two groups (P＞ 0.05). After intervention, the total score and dimension scores of PTGI of patients in observation group were higher than those in control group with statistical differences (P＜0.01). Before intervention, there were also no statistical differences in the total score and dimension scores of life quality of patients between two groups (P＞0.05). After intervention, the total score and dimension scores of life quality of patients in observation group were higher than those in control group with statistical differences (P＜0.01). Conclusions? Mindfulness-based stress reduction can improve post-traumatic growth and quality of life among postoperative breast cancer patients.