Journal of Korean Thyroid Association  2012;5(1):25-30

doi:10.11106/jkta.2012.5.1.25

Effect of Prolonged TSH Suppression on Cardiovascular System.

Jong Min SONG 1

Affiliations

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Keywords

Cardiovascular system; Thyrotoxicosis; Thyrotrophs

Country

Republic of Korea

Language

Korean

Abstract

Prolonged thyroid-stimulating hormone (TSH) suppression caused by exogenous subclinical thyrotoxicosis has been reported to impose harmful effects on cardiovascular system. Those effects involve increase in heart rate and myocardial mass, impaired ventricular diastolic and systolic function, decreased exercise capacity, decreased arterial elasticity, development of atrial tachyarrhythmia, and increase in cardiovascular adverse events. Tailored dose adjustment of thyroid hormone under the guidance of TSH level for obviating oversuppression of TSH, and use of beta blockers can reduce cardiovascular adverse effects in patients who undergo thyroid hormone therapy.