Objective To analyze the influencing factors of undergraduate nursing students′professional attitude in Xinjiang, so as to provide references for the educational guidance and decision-making management of nursing students′ professional attitude. Methods A questionnaire survey about professional attitude was conducted among 218 students of 2010-2013 full-time nursing students from Xinjiang Medical University and Shihezi University by convenience sampling method. Results The average score of nursing students′professional attitude was (3.80±0.67), which was in the “general” level. Univariate analysis showed that the professional attitude scores were significantly different among students with different gender, different choice, different parents′ education level, as well as whether they belong to one-child family ( P<0. 05 ) . Conclusions The professional attitude score of undergraduate nursing students was low. Nursing educators and administrators should implement targeted professional education, correct nursing students′ professional attitude, and keep the nursing team stable. Meanwhile, we also should retain talents and make good use of talents, so that to promote the sustainable development of nursing career.