Journal of Clinical Urology 2000;15(10):447-448

doi:10.3969/j.issn.1001-1420.2000.10.006

The effect of MMF on the post-operative infections after renal transplantation

Li-Gong TANG 1 ; Tie-Jun PAN ; Sen XIE ; Guo-Qin SHEN ; Hen-Dong WEN ; Jie-Rong YANG

Affiliations

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Keywords

Renal transplantation MMF Immunosuppressive agents Infection

Country

China

Language

Chinese

Abstract

Purpose:To investigate the effect of MMF on the postoperative infection after renal transplanta-tion. Methods: Before 1997, the CsA + Aza + prednisone were used as immunosuppresive agents postoperativelyfor 56 cases; Since 1998, drugs used for 34 cases were changed into MMF and CsA+MMF+prednisone respec-tively. The dose initially used for CsA was 65 mg/kg · d 1 in the patients of Aza group and 5 mg/kg · d 1 for theMMF group and then this dosage was regulated according to the determination of plasma level of the drug. Re-sults:The total infection rate of these 90 patients was 17.8%, 12 cases were infected in the Aza group (21.4%)and 11.8% (4 cases) in the MMF group. There were 2 patients died in the Aza group. Conclusions:The postop-erative infection rate of the patients underwent kidney transplantation might be reduced when MMF was used tosubstitute Aza during the period of postoperative management.