Journal of Clinical Urology 2000;15(10):441-442

doi:10.3969/j.issn.1001-1420.2000.10.003

Detection of endothelin and nitric oxide in renal allograft recipients

Wei-Zhen WU 1 ; Jiang CHENG ; Rong-Xi LIN ; Jian-Min TANG ; Yi YU

Affiliations

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Keywords

Kidney transplantation Endothelin Nitric oxide Rejection

Country

China

Language

Chinese

Abstract

Purpose:To investigate the clinical significance of endothelin(ET) and nitric oxide(NO) analysisin renal allograft recipients. Methods:Blood ET-1 and NO were measured in 32 cases of renal allograft recipients.Results:The ET-1 levels reduced( P＜0.05) and NO levels rose( P＜0.01) after renal transplantation. In pa-tients with acute rejection, the NO level was markedly higher than that in normal group and in chronic rejectiongroup( P＜0.01). In patients with chronic rejection, the ET-1 level was higher than that in normal group( P＜0.01). While the NO level was lower than that in patients with hypertension. Conclusions:The analysis of bloodET-1 and NO would be used to diagnose renal allograft rejection, and contribute to the anti-damage treatment ofgraft after renal transplantation.