Objective To investigate the effect of nursing intervention on the anxiety and depressinn of patients with coronary stenting implantation.Methods From August 2009 to June 2011,110 patients with coronary stenting implantation were randomly divided into control group and observation group,each group was 55 cases.The control group received routine nursing,while the observation group were given nursing intervention measures on the basis of routine nursing,and all patients were examined and analyzed with Zung Self-rating Anxiety Scale(SAS) and Self-rating Depression scale (SDS) after 6 months,and the anxiety and depression changes were observed and evaluated.Results After the intervention,the scores of SAS and SDS of observation group respectively were (36.21 ± 9.07) and (42.24 ± 9.06),and those of control group were (48.33 ± 9.02)and (52.36 ± 7.53),and the difference were statistically significant (x2 =9.354,7.872 ; P ＜ 0.05).The depression and anxiety rate of observation group (21.82％ and 32.73％) were significantly lower than those of control group after nursing intervention (21.82％ vs 41.82％,32.72％ vs 47.27％ ;x2 =9.354,7.872;P ＜0.05).Conclusions It can effectively reduce the incidence of anxiety and depression in patients with coronary stenting implantation through the nursing intervention,and improve the patients' quality life.