Objective To observe the effects of the combination of aloe and vitamin E in the prevention of irradiation-induced acute skin injury.Methods 138 cases with malignant tumors who received first radiation under linear accelerator were randomized into prevention group (n=70) and control group (n= 68 ).Among the prevention group, patients were applied with fresh aloe fluids on radiation sites until they were dry before radiation.After each radiation, the radiation sties were cleaned with cool boiled water and applied with vitamin E.If skin lesion occurred, times of local use of aloe and vitamin E could be increased.In the control group, no skin protection measures were used.If skin lesion occurred, local use of norfloxacin or Genetime spray(recombinant human epidermal growth factor derivative).RTOG scores were used to assess skin integrity of radiation sites in both groups everyday till all radiations were completed.Results Skin reaction rate and grade in prevention group were significantly less than those in the control group and the time occurring skin lesion in prevention group was significantly delayed (P＜0.05).Conclusions The combination of aloe and vitamin E is effective in preventing and controlling irradiation-induced skin injury.