Objective To study effect of targeted nursing cooperation on complications of endoscopic thyroidectomy.Methods A total of 104 patients with endoscopic thyroidectomy in our hospital were divided into study group and control group by random number table method,with 52 cases in each group.Control group conducted conventional nursing for endoscopic thyroidectomy,study group conduced targeted nursing cooperation on the basis of the control group.Operation time,postoperative volume of drainage,length of hospital stay,and intraoperative complications were compared.Results No significant differences in operation time and volume of drainage between two groups were found(P ＞0.05);Incidence rate of complications and length of hospital stay were lower than that in the control group (P ＜ 0.05).Conclusion Targeted nursing can effectively reduce incidence rate of complications in endoscopic thyroidectomy,speed up the recovery,and had no significant effect on operation time and postoperative volume of drainage,so it is suitable for clinical promotion.