Objective To investigate the effect of 0.45 ％ saline for airway humidification in patients with craniocerebral injury after tracheotomy.Methods A total of 58 patients with craniocerebral injury after tracheotomy treated in our department were as observation group,given 0.45％ saline for airway humidification.And 40 craniocerebral injury patients after tracheotomy at the same time were as control group,given sterilized saline for airway humidification.The effect of airway humidification,the rate of sputum scab formation,and the incidence of adverse reactions were compared between the two groups.Results The pH of sputum after 3,5 d of tracheotomy in the observation group was lower (P ＜ 0.05),but the effect of airway humidification and the rate of sputum scab formation in the two groups showed no statistically significant difference (P ＞ 0.05).The incidence of pulmonary infection,irritating cough and respiratory mucosal bleeding in the observation group were lower than that in the control group (P ＜ 0.05).Conclusion The 0.45％ saline solution for airway humidification is in accordance with the physiological needs of the patients,and has better wetting effect and lower incidence of adverse events.