Chinese Journal of Clinical Medicine 2014;(3):242-244

Expression and Clinical Significance of UHRF1 in Hepatocellular Carcinoma

Guoming SHI 1 ; Jiabin CAI ; Jingxian YU ; Aiwu KE ; Zhaoru DONG ; Chi ZHANG ; Pengfei ZHANG ; Shuangjian QIU ; Huichuan SUN ; Jian ZHOU ; Jia FAN

Affiliations

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Keywords

Hepatocellular carcinoma; Ubiquitin-like; containing PHD and RING finger domains 1; Clinicopathological characteristics; Epigenetics

Country

China

Language

Chinese

Abstract

Objective:To study the expression of UHRF1 and its relationships with the clinicopathological characteristics in hepatocellular carcinoma(HCC) .Methods :The expression of UHRF1 was analyzed in 556 cases of tumor tissues and peritumor tissues of HCC by immunohistochemistry .The relationships of UHRF1 with the clinicopathological characteristics of HCC were assayed .Results:Immunohistochemistry showed that positive staining of UHRF1 located in the nucleus of HCC cells .The ex-pression levels of UHRF1 protein were higher in tumor tissues than in peritumor tissues .HCC patients with positive expression of UHRF1 protein accounted for 59% of the whole cohort .The expression of UHRF1 protein was significantly correlated with the size of tumor ( P<0 .01) ,differentiation (P<0 .05) and microvessel invasion(P<0 .01) .Conclusions :The overexpression of UHRF1 is correlated with the malignant phenotypes of HCC and probably implicated in the invasion and metastasis of HCC .