OBJECTIVE This paper is to discuss possible targets in the treatment of heart failure with reduced left ventricu-lar ejection fraction(HFREF) with QiangXinKang by observing the effect of QiangXinKang on the brain natriuretic peptide (BNP)and red blood cell volume distribution width(RDW)of patients with HFREF.METHODS 198 patients meeting the selecting criteria of HFREF were randomly divided into the experimental group with 102 cases and the control group with 96 cases.Both groups received routine treatments conforming to Guideline for the Diagnosis and Treatment for Heart Failure (2007 Edition) and the experimental group took QiangXinKang additionally.After 4-week treatment,changes of BNP,RDW level and LVEF were compared between the two groups before and after treatment.RESULTS As LVEF was improved after treatment,BNP concentration and RDW level of patients in both groups were significantly reduced,while those of the experi-mental group decreased more significantly,which showed a significant difference between the two groups (P<0.05).CON-CLUSION QiangXinKang may significantly reduce the BNP and RDW level and improve the heart function of patients with HFREF.