Clinical Psychopharmacology and Neuroscience  2016;14(3):305-310

doi:10.9758/cpn.2016.14.3.305

Clinical Usefulness of Aripiprazole and Lamotrigine in Schizoaffective Presentation of Tuberous Sclerosis.

Seung Yup LEE 1 ; Jung Ah MIN ; In Goo LEE ; Jung Jin KIM

Affiliations

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Keywords

Aripiprazole; Lamotrigine; Schizoaffective disorder; Tuberous sclerosis

Country

Republic of Korea

Language

English

Abstract

Tuberous sclerosis is not as rare as once thought and has high psychiatric comorbidities. However, bipolar or psychotic features associated with tuberous sclerosis have been rarely reported. This report first presents a tuberous sclerosis patient, resembling a schizoaffective disorder of bipolar type. A patient with known tuberous sclerosis displayed mood fluctuation and psychotic features. Her symptoms did not remit along with several psychiatric medications. After hospitalization, the patient responded well with lamotrigine and aripiprazole without exacerbation. As demonstrated in this case, tuberous sclerosis may also encompass bipolar affective or psychotic features. We would like to point out the necessity to consider bipolarity in evaluating and treating tuberous sclerosis.