Objective To explore the nursing points of anxiety and depression in the pa-tients with viral hepatitis treated with interferon.Methods 134 hepatitis patients treated with an-tiviral therapy were randomly divided into intervention group and control group,the control group was given routine nursing while the intervention group was given comprehensive nursing interven-tion.Psychological status of the patients was assessed with hospital anxiety and depression scale. Results Incidence rate of depression and anxiety after intervention in the intervention group sig-nificantly reduced than that in the control group,the difference was statistically significant after in-tervention(P <0.05).Occurrence rate of anxiety and depression in the control group before and after nursing intervention showed no statistical significance.Conclusion The comprehensive nursing measures of psychological and behavioral intervention can improve the anxiety and depres-sion in patients with viral hepatitis and it is favorable to antiviral hepatitis treatment and life quality of patients.