Objective To discuss the relevant factors and nursing measures of indwelling nasal duct for prevention of pancreatitis after endoscopic sphincterotomy (EST).Methods Retrospective study method was adopted to analyze the relevant factors of 60 post-EST patients with endoscopic nasobiliary drainage in Department of Gastroenterology and summarize purposeful nursing measures. Results Smooth and effective drainage,flushing methods of drainage tube,Timely and correct ob-servation and treatment,and comfortable degree of the patients were relevant effective factors for prevention of post-EST pancreatitis.Conclusion Purposeful nursing measures were adopted to control and reduce the incidence of pancreatitis after analysis of relevant factors of indwelling nasal duct after EST.