Objective:To evaluate the analgesic effect from the ethanolic extract of Potentilla freyniana Bornm. var. Sinica Migo (PBSM).Methods:The analgesic properties of PBSM were investigated by the classical hot plate test and the writhing test.Results:In the hot plate test,the ethanolic extract of PBSM(0.5g/kg,1.25 g/kg,2.5g/kg,o.p.) significantly delayed the response time to hot-plate thermal stimulation 15,30,60 and 90 min after treatment,and 90 min after treatment,the effect of PBSM (2.5g/kg) was higher than that of aminopyrine (100 mg/kg i.m.).In the writhing test, which is more sensitive for non-steroidal analgesics, the ethanolic extract of PBSM (0.5g/kg,1.25g/kg,2.5g/kg o.p.) dose significantly inhibited the writhes induced by 0.7% acetic acid.Conclusion:Potentilla freyniana Bornm.var.Sinica Migo may have analgesic activity and affirm the claim by traditional medicine practitioners of the use in toothache or some painful conditions.