Objective To evaluate the clinical efficacy and safety of polyene phosphatidylcholine capsule combined with Jueming Jiangzhi tablets in the treatment of nonalcoholic fatty liver disease.Methods A total of 62 patients with nonalcoholic fatty liver disease were randomly divided into control group and treatment group,each group 31 cases.Patients in control group were given polyene phosphatidylcholine capsule 456 mg,three times a day.Patients in treatment group were given Jueming Jiangzhi tablets 2.7 g,3 times a day on the basis of control group.All patients were treated for 2 months.The clinical efficacy,leptin,level of liver function and adverse drug reactions in two groups were compared.Results After treatment,the total effective rate of treatment group was 87.10％ (27/31),had significant difference with that in control group,which was 64.52％ (20/31,P ＜ 0.05).After treatment,the serum leptin in control group and treatment group were (1.08 ± 0.17),(0.76 ± 0.89) μg · L-1,alanine aminotransferase were (50.82 ± 5.59),(34.97 ± 4.03) U· L-1,aspartate aminotransferase were (54.92 ± 6.02),(40.25 ± 4.53) U · L-1,total bilirubin were (30.11 ± 3.35),(27.89 ± 3.09) μmol · L-1,direct bilirubin were (18.02 ± 2.01),(13.60 ± 1.67) μmol · L-1,albumin were (35.92 ±4.45),(42.03 ±4.70) g · L-1,the difference had statistically significant (P ＜ 0.05).The adverse drug reactions in treatment group were mild gastrointestinal disorders,dizziness,headache,rash,total incidence rate of adverse reactions was 9.68％ (3/31 cases).The adverse drug reactions in control group were dizziness headache,vertigo,headache,rash,cirrhosis,total incidence rate of adverse drug reaction was 22.58％ (7/31 cases,P ＞ 0.05).Conclusion Polyene phosphatidylcholine capsule combined with Jueming Jiangzhi tablets in the treatment of nonalcoholic fatty liver disease have a higher clinical efficacy,high safety.