Objective To analyze effect of clinical pharmacist intervention on drug compliance and efficacy of patients after acute cerebral infarction.Methods A total of 73 patients with acute cerebral infarction and intervention were randomly divided into control group (36 cases) and treatment group (37 cases).At the time of discharge,the control group adopted conventional nurse dispensing and short-answer presentation mode.The treatment group was instructed by the clinical pharmacist.Six months later,follow-up and evaluation of the two groups of patients with drug effects and compliance.Results The total effective rate was 70.27％ (26/37 cases) and 47.22％ (17/36 cases) in the treatment group and the control group,respectively.The overall pass rate of the mastery of medication was 78.38％ (29/37 cases) and 52.78％ (19/36 cases).The rate of drug withdrawal was 56.76％ (21/37 cases) and 30.56％ (11/36 cases) respectively.The rates of automatic withdrawal were 0 (0/37 cases) and 19.44％ (7/36 cases) There was statistical significance (P ＜ 0.05).Conclusion Clinical pharmacist intervention can significantly improve the therapeutic effect of patients with acute cerebral infarction after intervention,which improve the degree of medication and medication compliance.