Objective To observe the pharmacological effect of Mansh-enling granules on chronic renal failure (CRF) induced by daunorubicin in rats. Methods CRF was induced with injecting daunorubicin repeat-edly after uninephrectomy. In addition normal group, the CRF Wistar rats were randomly divided in to 5 groups: model group, control group (Niaoduqing granules 2.3 g·kg-1 ), and large, middle, small dose ( Manshenling granules 2.70、1.35,0. 68 g·kg-1) test groups. The ne-phroprotective effects of Manshenling granules was investigated. Results In large and middle groups, serum creatinine, BUN and urinary protein were significantly decreased than those in model group. Glomerul- cell prolifera-tion and glomerular sclerosis level were slighter than in model group. Con-clusion Manshenling granules can reduce the injury of renal in CRF rats.