Objective To evaluate the effect of calcium dobesilate cap-sule combining compound dansen dropping pill treating diabetic retinopa-thy and diabetic nephyopathy. Methods Sixty -five patients with dia-betic retinopathy and diabetic nephyopathy were randomlied into two groups, control group ( compound dansen dropping pill po 500 mg, rid, n = 32) ; trial group ( compound dansen dropping pill po 500 mg + calciumdobesilate po 270 mg, tid, n = 33 ) for three months. The change of eye ground,blood rheology, serum creatinine, urea nitrogen,24 hours urine protein were Observe. Results Trial group were obviously mult than control group about eye ground improved, ang aggravated obviously re-dueed. (P<0.01 ). Trial group degrade blood rheology and urine pro-tein, discharge degrade serum creatinine and urea nitrogen, to lessen kid-ney damage, protection kidney were more obviously than control group.Conclusion The effect of treating diabetic retinopathy and diabetic nephyopathy by combining calcium dobesilate pill and compound dansen dropping pill were good than take compound dansen dropping pill alone.