Chinese Journal of Clinical Medicine 2025;32(1):15-23

doi:10.12025/j.issn.1008-6358.2025.20241533

Application progress of Yttrium-90 microsphere selective internal radiation therapy on metastatic liver cancer

Guanxiang ZHUO 1 ; Linhe GAN 1 ; Jinfeng LIAN 1 ; Yilin WANG 2

Affiliations

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Keywords

metastatic liver cancer; Yttrium-90 microsphere; selective internal radiation therapy; interventional therapy

Country

China

Language

Chinese

Abstract

Yttrium-90 microsphere selective internal radiation therapy (90Y-SIRT) has been widely used in the treatment of malignant liver cancers, and its safety and efficacy have been fully validated. As an important local therapeutic method, 90Y-SIRT has been utilized for the treatment of multiple metastatic liver cancers in many cancer diagnosis and treatment centers at home and abroad, demonstrating significant therapeutic potential. This article reviews the basic principle, development history, indications and contraindications of 90Y microsphere, as well as the specific applications in treatment of different types of metastatic liver cancers, aiming to provide references for further research and optimization of treatment strategies.