Journal of Pharmaceutical Practice and Service 2025;43(2):47-50

doi:10.12206/j.issn.2097-2024.202309023

Research progress on ANXA3 gene and protein

Tingting FENG 1 ; Jingxiang ZHANG 2 ; Yan WANG 2 ; Weiheng XU 2 ; Junping ZHANG 3

Affiliations

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Keywords

Annexin A3; structural function; disease mechanism

Country

China

Language

Chinese

Abstract

Annexin A3（ANXA3）is a member of the membrane associated protein family. It has two subtypes of 36 kDa and 33 kDa. Its gene is located on the fourth chromosome of human. ANXA3, widely expressed in human bone marrow, lung, placenta, prostate and thyroid, is closely related to several biological processes such as exoplasmosis, vascular production, fat cell maturity, and white blood cell migration. Studies have found that ANXA3 is abnormally expressed in various diseases including cancer, cardiovascular disease and inflammation. It can regulate multiple signaling pathways such as JNK, NF-κB, PI3K/AKT, and may become a potential drug target for treatment of related diseases. The structure, functions, the link with diseases and related mechanisms of ANXA3 were summarized in this paper, which could provide reference for ANXA3 related research.