Journal of Public Health and Preventive Medicine 2025;36(1):1-7

doi:10.3969/j.issn.1006-2483.2025.01.001

Study on the relationship between hypothalamus extended synaptotagmins and energy balance regulation

Yunliang GUAN 1 ; Guo ZHANG 2

Affiliations

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Keywords

Energy balance; Endoplasmic reticulum-plasma membrane junction; Endoplasmic reticulum stress; Hypothalamus; Extended synaptotagmins

Country

China

Language

Chinese

Abstract

Obesity is an important manifestation of the imbalance of energy regulation, and its complications can cause irreparable damage to the body. Finding the pathogenesis of obesity at the molecular level can help fundamentally avoid these irreversible complications. Extended synaptotagmins (E-Syts) are proteins related to the formation of endoplasmic reticulum (ER) and plasma membrane (PM). Because of the short discovery time, there is huge room for exploration. In terms of the role of the established structure of E- Syts at the molecular level, it has a non-negligible link with the pathogenesis of obesity. Starting with the structure of hypothalamus, this paper reviews the literature evidence of this connection, hoping to find a new research angle for reducing the incidence of obesity.